1,4-Dioxane hydrochloride → HCID 67455706, compound

HRID 1713319Notes

Reaction equation

HRID 1713319 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([CH2:15][NH:16]C(=O)OC(C)(C)C)[CH:12]=[CH:11][C:10]=1[C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([C:30](=[O:34])[N:31]([CH3:33])[CH3:32])[CH:25]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O1CCOCC1.[ClH:41]>>[ClH:41].[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([CH2:15][NH2:16])[CH:12]=[CH:11][C:10]=1[C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([C:30](=[O:34])[N:31]([CH3:32])[CH3:33])[CH:25]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67457314HCID 67457314, compound

Product 1

HCID 67455706HCID 67455706, compound

Procedure

tert-Butyl N-(2-benzyloxy-3′-dimethylcarbamoyl-biphenyl-4-ylmethyl)carbamate (0.7 g) was suspended in 4 mol/L hydrogen chloride-1,4-dioxane solution (7.0 mL), and the resulting mixture was stirred at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure to give the title compound (0.55 g).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-00edabcfb64642fba583c470423978f6
Source dataset
uspto-grants-2010_09
Patent number
US07795236B2

Reaction notes

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