反应详情

60 g (413 mmol) of 2H-isoquinolin-1-one (=isocarbostyril) are dissolved in 1 l of glacial acetic acid and, after addition of 2.3 g (10 mmol) of platinum(IV) oxide, hydrogenated under 3 bar at RT until conversion is complete. This entailed changing the catalyst after 3 days and a further 5 days. The suspension is filtered, concentrated and again concentrated after addition of toluene. The crude product is recrystallized from 1.6 l of water. Long needles are filtered off, and the mother liquor is concentrated and dried and separated on silica gel. 36.8 g (60%) of a colorless oil are obtained.

1. customat RT
2. customafter 3 days
3. customa further 5 days
4. filtrationThe suspension is filtered
5. concentrationconcentrated
6. concentrationagain concentrated
7. additionafter addition of toluene
8. customThe crude product is recrystallized from 1.6 l of water
9. filtrationLong needles are filtered off
10. concentrationthe mother liquor is concentrated
11. customdried
12. customseparated on silica gel