Hydrogen Bromide → 5-Methyl-thiophene-2-carboxylic acid (4-{2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-thiazol-2-yl)-amide

HRID 171340Notes

Reaction equation

HRID 171340 reaction equation
[BrH:1].[BrH:2].[BrH:3].[CH3:26][c:27]1[cH:28][cH:29][c:30]([C:32](=[O:33])[OH:34])[s:31]1.[NH2:4][c:5]1[s:6][cH:7][c:8]([CH2:10][C:11](=[O:12])[N:13]2[CH2:14][CH2:15][N:16]([CH:19]3[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24]3)[CH2:17][CH2:18]2)[n:9]1>>[NH:4]([c:5]1[s:6][cH:7][c:8]([CH2:10][C:11](=[O:12])[N:13]2[CH2:14][CH2:15][N:16]([CH:19]3[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24]3)[CH2:17][CH2:18]2)[n:9]1)[C:32]([c:30]1[cH:29][cH:28][c:27]([CH3:26])[s:31]1)=[O:33]

Participants

4

Reactant 3

HCID 260Hydrogen Bromide3×HCID 747135-Methylthiophene-2-carboxylic acidHCID 596988322-(2-Amino-1,3-thiazol-4-yl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]ethanone

Product 1

HCID 596988685-Methyl-thiophene-2-carboxylic acid (4-{2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-thiazol-2-yl)-amide

Sources & evidence

ORD record
ord-c8872d95c83d460ab276588f7363073a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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