Potassium Hydroxide → HCID 59463817, compound

HRID 1713402Notes

Reaction equation

HRID 1713402 reaction equation
C[O:2][C:3]1[C:12]2[CH2:11][CH2:10][CH2:9][CH2:8][C:7]=2[C:6]([NH:13][C:14]2[CH:15]=[C:16]([CH:22]=[CH:23][CH:24]=2)[C:17]([O:19]CC)=[O:18])=[CH:5][N:4]=1.[OH-].[K+]>C(O)C>[O:2]=[C:3]1[C:12]2[CH2:11][CH2:10][CH2:9][CH2:8][C:7]=2[C:6]([NH:13][C:14]2[CH:15]=[C:16]([CH:22]=[CH:23][CH:24]=2)[C:17]([OH:19])=[O:18])=[CH:5][NH:4]1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 59463818HCID 59463818, compound2×

Product 1

HCID 59463817HCID 59463817, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

180 mg (0.58 mmol) of ethyl 3-(1-methoxy-5,6,7,8-tetrahydroisoquinolin-4-ylamino)benzoate (compound 38) are introduced into 3 ml of ethanol and, at room temperature, 3 ml of 2N KOH are added. After two hours, the solvent is removed in vacuo and the residue is taken up in 5 ml of H2O and acidified with 2N HCl. The resulting precipitate is filtered off with suction and dried. Yield: 123 mg (75%).

Workup

  1. customthe solvent is removed in vacuo
  2. filtrationThe resulting precipitate is filtered off with suction
  3. customdried

Sources & evidence

ORD record
ord-54a7b552e6534ec492e3707ffb30685b
Source dataset
uspto-grants-2010_09
Patent number
US07795278B2

Reaction notes

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