Potassium Hydroxide → HCID 59463817, compound

Participants

Reaction Steps

180 mg (0.58 mmol) of ethyl 3-(1-methoxy-5,6,7,8-tetrahydroisoquinolin-4-ylamino)benzoate (compound 38) are introduced into 3 ml of ethanol and, at room temperature, 3 ml of 2N KOH are added. After two hours, the solvent is removed in vacuo and the residue is taken up in 5 ml of H2O and acidified with 2N HCl. The resulting precipitate is filtered off with suction and dried. Yield: 123 mg (75%).

Provenance & Evidence