Sodium Bicarbonate → Ethyl 1,4-dibenzylpiperazine-2-carboxylate

HRID 1713480Notes

Reaction equation

HRID 1713480 reaction equation
Cl.Cl.[C:3]1([CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:12][CH:11]2[C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(=O)([O-])O.[Na+]>>[C:3]1([CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH2:12][CH:11]2[C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 516892Sodium BicarbonateHCID 68419710Ethyl 1,4-dibenzylpiperazine-2-carboxylate dihydrochloride

Product 1

HCID 2736402Ethyl 1,4-dibenzylpiperazine-2-carboxylateYield 102.3%

Procedure

Ethyl 1,4-bis(phenylmethyl)-2-piperazine carboxylate dihydrochloride (21 g, 52 mmol) was neutralized with an aqueous sodium hydrogen carbonate solution, and then extracted with ethyl acetate. The extract was washed with water, dried over magnesium sulfate, and then concentrated under reduced pressure to obtain the title compound (18 g, quantitative). The obtained compound was used in the next process without further purification.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with water
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-600ba5550aac4b6fa04adce9de750e6f
Source dataset
uspto-grants-2010_09
Patent number
US07795267B2

Reaction notes

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