反应详情

To a solution of 1,1-dimethylethyl 1,1-bis(phenylmethyl)-tetrahydro-3-oxo-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxylate (1.3 g, 3.2 mmol) in dichloromethane (15 mL) was added trifluoroacetic acid (4 mL), and the mixture was stirred at room temperature for 4 hours. The reaction solution was concentrated and extracted with ethyl acetate. The extract was washed with a 0.5 M aqueous sodium hydrogen carbonate solution, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. To the residue was added diethyl ether, the resulting crystals were collected by filtration and washed with diethyl ether to obtain the title compound (0.86 g, yield 85%).

1. concentrationThe reaction solution was concentrated
2. extractionextracted with ethyl acetate
3. washThe extract was washed with a 0.5 M aqueous sodium hydrogen carbonate solution
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated under reduced pressure
6. additionTo the residue was added diethyl ether
7. filtrationthe resulting crystals were collected by filtration
8. washwashed with diethyl ether