Flt-3 Inhibitor III → N-[3-[(Dimethylamino)methyl]phenyl]-5-phenyl-2-thiazolamine

HRID 1713634Notes

Reaction equation

HRID 1713634 reaction equation
[C:1]1([C:7]2[S:11][C:10]([NH:12][C:13]3[CH:18]=[CH:17][C:16](OCCN4CCCC4)=[CH:15][CH:14]=3)=[N:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:27][N:28]([CH2:30]C1C=C(NC(N)=S)C=CC=1)[CH3:29]>C(Cl)Cl.CO>[CH3:27][N:28]([CH2:30][C:17]1[CH:18]=[C:13]([NH:12][C:10]2[S:11][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:8][N:9]=2)[CH:14]=[CH:15][CH:16]=1)[CH3:29]

Participants

4

Reactant 2

HCID 11772958Flt-3 Inhibitor IIIHCID 18621787(3-Dimethylaminomethyl-phenyl)-thiourea

Product 1

HCID 11243816N-[3-[(Dimethylamino)methyl]phenyl]-5-phenyl-2-thiazolamine

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared as described in Example 1 for (5-phenyl-thiazol-2-yl)-[4-(2-pyrrolidin-1-yl-ethoxy)phenyl]-amine but using (3-dimethylaminomethyl-phenyl)-thiourea. Title compound: ES-MS: 310.1 [M+H]+; single peak at tR=6.65 min (System 1); Rf=0.63 (CH2Cl2/MeOH, 80/20).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-76a4dd3cd0244474a1b21a749cf3e666
Source dataset
uspto-grants-2010_09
Patent number
US07795288B2

Reaction notes

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