3-amino-N,N-dimethylbenzylamine → HCID 18621787, compound

HRID 1713635Notes

Reaction equation

HRID 1713635 reaction equation
[N:1]1(CCOC2C=CC(NC(N)=O)=CC=2)CCCC1.[N:19]([C:22]1[CH:23]=[C:24]([CH:29]=[CH:30][CH:31]=1)[CH2:25][N:26]([CH3:28])[CH3:27])=[C:20]=[S:21].N(C1C=CC(OCCN2CCCC2)=CC=1)=C=S.CN(CC1C=C(N)C=CC=1)C>C(Cl)Cl.CO>[CH3:27][N:26]([CH2:25][C:24]1[CH:23]=[C:22]([NH:19][C:20]([NH2:1])=[S:21])[CH:31]=[CH:30][CH:29]=1)[CH3:28].[N:19]([C:22]1[CH:23]=[C:24]([CH:29]=[CH:30][CH:31]=1)[CH2:25][N:26]([CH3:28])[CH3:27])=[C:20]=[S:21]

Participants

7

Reactant 4

HCID 992943-amino-N,N-dimethylbenzylamineHCID 118461221-(2-(4-Isothiocyanatophenoxy)ethyl)pyrrolidineHCID 59689650HCID 59689650, compoundHCID 68704441[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-urea

Product 2

HCID 18621787HCID 18621787, compoundHCID 59689650HCID 59689650, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared as described in Example 1 for [4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-urea but using (3-isothiocyanato-benzyl)-dimethyl-amine. Title compound: ES-MS: 210.0 [M+H]+; single peak at tR=3.38 min (System 1); Rf=0.63 (CH2Cl2/MeOH, 80/20). (3-Isothiocyanato-benzyl)-dimethyl-amine is prepared as described in Example 1 for 1-[2-(4-isothiocyanato-phenoxy)ethyl]-pyrrolidine but using 3-dimethylaminomethyl-phenylamine. (3-Isothiocyanato-benzyl)dimethyl-amine is obtained and used as an impure crude material.

Workup

  1. customThe title compound is prepared
  2. custom(3-Isothiocyanato-benzyl)-dimethyl-amine is prepared

Sources & evidence

ORD record
ord-cda9356e9d114220b1e49b432a91ff9d
Source dataset
uspto-grants-2010_09
Patent number
US07795288B2

Reaction notes

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