1-(4-Isothiocyanatophenyl)-4-methylpiperazine → [4-(4-Methylpiperazin-1-yl)phenyl]thiourea

HRID 1713640Notes

Reaction equation

HRID 1713640 reaction equation
[N:1]1(CCOC2C=CC(NC(N)=O)=CC=2)CCCC1.[N:19]([C:22]1[CH:27]=[CH:26][C:25]([N:28]2[CH2:33][CH2:32][N:31]([CH3:34])[CH2:30][CH2:29]2)=[CH:24][CH:23]=1)=[C:20]=[S:21]>C(Cl)Cl.CO>[CH3:34][N:31]1[CH2:30][CH2:29][N:28]([C:25]2[CH:24]=[CH:23][C:22]([NH:19][C:20]([NH2:1])=[S:21])=[CH:27][CH:26]=2)[CH2:33][CH2:32]1

Participants

4

Reactant 2

HCID 137183971-(4-Isothiocyanatophenyl)-4-methylpiperazineHCID 68704441[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-urea

Product 1

HCID 39146979[4-(4-Methylpiperazin-1-yl)phenyl]thiourea

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared as described in Example 1 for [4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-urea but using 1-(4-isothiocyanato-phenyl)-4-methyl-piperazine and stirring the reaction mixture at RT for 17 h. Title compound: ES-MS: 251.0 [M+H]+; major peak at tR=3.56 min (System 1); Rf=0.27 (CH2Cl2/MeOH, 80/20).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-746305e35e8f487e818aa19cb3104da5
Source dataset
uspto-grants-2010_09
Patent number
US07795288B2

Reaction notes

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