4-(2-(Pyrrolidin-1-yl)ethoxy)aniline → 4-[2-(Dimethylamino)ethoxy]aniline

HRID 1713645Notes

Reaction equation

HRID 1713645 reaction equation
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)[CH2:5]CC[CH2:2]1.Cl.ClCCN(C)C>C(Cl)Cl.CO>[CH3:2][N:1]([CH3:5])[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 64937494-(2-(Pyrrolidin-1-yl)ethoxy)anilineHCID 11636816N,N-Dimethylaminoethyl chloride hydrochloride

Product 1

HCID 64846554-[2-(Dimethylamino)ethoxy]aniline

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared as described in Example 1 for 4-(2-pyrrolidin-1-yl-ethoxy)-phenylamine but using 1-chloro-2-dimethylaminoethane hydrochloride. Title compound: ES-MS: 181.2 [M+H]+; Rf=0.18 (CH2Cl2/MeOH, 70/30).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-9114ea4742c84653a832183649c7710b
Source dataset
uspto-grants-2010_09
Patent number
US07795288B2

Reaction notes

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