Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) → HCID 58923515, compound

HRID 1713659Notes

Reaction equation

HRID 1713659 reaction equation
CN(C)CCCOC1C=CC(C2SC(NC3C=CC=CC=3)=NC=2)=CC=1.[S:26]1[CH:30]=[CH:29][C:28]([C:31]2[S:35][C:34]([NH:36][C:37]3[CH:42]=[CH:41][C:40]([OH:43])=[CH:39][CH:38]=3)=[N:33][CH:32]=2)=[CH:27]1.Cl.Cl[CH2:46][CH2:47][N:48]1[CH2:53][CH2:52][O:51][CH2:50][CH2:49]1>>[N:48]1([CH2:47][CH2:46][O:43][C:40]2[CH:41]=[CH:42][C:37]([NH:36][C:34]3[S:35][C:31]([C:28]4[CH:29]=[CH:30][S:26][CH:27]=4)=[CH:32][N:33]=3)=[CH:38][CH:39]=2)[CH2:53][CH2:52][O:51][CH2:50][CH2:49]1

Participants

4

Reactant 3

HCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)HCID 11245147{5-[4-(3-Dimethylamino-propoxy)-phenyl]-thiazol-2-yl}phenyl-amineHCID 112888354-(5-Thiophen-3-yl-thiazol-2-yl-amino)-phenol

Product 1

HCID 58923515HCID 58923515, compound

Procedure

The title compound is prepared as described in Example 8 for {5-[4-(3-dimethylamino-propoxy)-phenyl]-thiazol-2-yl}-phenyl-amine but starting from 4-(5-thiophen-3-yl-thiazol-2-yl-amino)-phenol (Example 12) and using (2-chloroethyl)-morpholine hydrochloride. MPLC (CH3CN/H2O/TFA) purification affords the title compound: ES-MS: 388.0 [M+H]+; single peak at tR=2.80 min (System 2).

Workup

  1. customThe title compound is prepared
  2. customMPLC (CH3CN/H2O/TFA) purification

Sources & evidence

ORD record
ord-8113d2ef660a4de7a4993e470fc3f862
Source dataset
uspto-grants-2010_09
Patent number
US07795288B2

Reaction notes

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