HuagongsheHuagongshe Chemistry Print Report · For research reference only
[4-(4-Methylpiperazin-1-yl)phenyl]thiourea → [4-(4-Methyl-piperazin-1-yl)-phenyl]-(5-thiophen-3-yl-thiazol-2-yl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [4-(4-Methylpiperazin-1-yl)phenyl]thiourea | HCID 39146979 | — |
| Reactant | (3-Dimethylaminomethyl-phenyl)-(5-thiophen-3-yl-thiazol-2-yl)-amine | HCID 58923521 | — |
| Product | [4-(4-Methyl-piperazin-1-yl)-phenyl]-(5-thiophen-3-yl-thiazol-2-yl)-amine | HCID 58923513 | — |
Reaction Steps
The title compound is prepared as described in Example 19 for (3-dimethylaminomethyl-phenyl)-(5-thiophen-3-yl-thiazol-2-yl)-amine but starting from [4-(4-methyl-piperazin-1-yl)-phenyl]-thiourea (Example 5). MPLC (CH3CN/H2O/TFA) purification affords the title compound: ES-MS: 357.1 [M+H]+; single peak at tR=2.82 min (System 2); Rf=0.59 (CH2Cl2/MeOH, 90/10).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795288B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-9e895797d27241eeb4daf53ed9b9f518 |
| Source note | uspto-grants-2010_09 |