4-(5-Thiophen-3-yl-thiazol-2-yl-amino)-phenol → 4-[5-(2-Chloro-phenyl)-thiazol-2-ylamino]-phenol

HRID 1713668Notes

Reaction equation

HRID 1713668 reaction equation
S1C=CC(C2[S:10][C:9]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=3)=[N:8]C=2)=C1.[Cl:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH2:26][CH:27]=O>C(Cl)Cl.CO>[Cl:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[C:26]1[S:10][C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)=[N:8][CH:27]=1

Participants

4

Reactant 2

HCID 112888354-(5-Thiophen-3-yl-thiazol-2-yl-amino)-phenolHCID 113786242-(2-Chlorophenyl)acetaldehyde

Product 1

HCID 589235284-[5-(2-Chloro-phenyl)-thiazol-2-ylamino]-phenol

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared as described in Example 12 (Procedure B) for 4-(5-thiophen-3-yl-thiazol-2-yl-amino)-phenol but starting from (2-chlorophenyl)-acetaldehyde. The title compound: ES-MS: 303.0 [M+H]+; single peak at tR=3.59 min (System 2); Rf=0.21 (CH2Cl2/MeOH, 95/5).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-8984deac894746eba4a238f8916e6664
Source dataset
uspto-grants-2010_09
Patent number
US07795288B2

Reaction notes

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