HuagongsheHuagongshe Chemistry Print Report · For research reference only
Flt-3 Inhibitor III → [4-(4-Methyl-piperazin-1-yl)-phenyl]-[5-(3-thiophen-3-yl-phenyl)-thiazol-2-yl]-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Flt-3 Inhibitor III | HCID 11772958 | — |
| Reactant | [4-(4-Methylpiperazin-1-yl)phenyl]thiourea | HCID 39146979 | — |
| Reactant | (3-Thiophen-3-yl-phenyl)-acetaldehyde | HCID 58923511 | — |
| Product | [4-(4-Methyl-piperazin-1-yl)-phenyl]-[5-(3-thiophen-3-yl-phenyl)-thiazol-2-yl]-amine | HCID 58923522 | — |
Reaction Steps
The title compound is prepared as described in Example 1 for (5-phenyl-thiazol-2-yl)-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine but using (3-thiophen-3-yl-phenyl)-acetaldehyde and [4-(4-methyl-piperazin-1-yl)-phenyl]-thiourea (Example 5). MPLC (CH3CN/H2O/TFA) purification affords the title compound: ES-MS: 435.0 [M+3]+; single peak at tR=3.09 min (System 2); Rf=0.25 (CH2Cl2/MeOH, 90/10).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795288B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-d730815b85634a6db9a8b14b4e2d31f9 |
| Source note | uspto-grants-2010_09 |