4-(5-Thiophen-3-yl-thiazol-2-yl-amino)-phenol → 4-[5-(3-Thiophen-3-yl-phenyl)-thiazol-2-ylamino]-phenol

HRID 1713674Notes

Reaction equation

HRID 1713674 reaction equation
S1[CH:5]=[CH:4][C:3]([C:6]2[S:10][C:9]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=3)=[N:8][CH:7]=2)=[CH:2]1.[S:19]1[CH:23]=[CH:22][C:21]([C:24]2C=C(CC=O)C=C[CH:29]=2)=[CH:20]1>>[S:19]1[CH:23]=[CH:22][C:21]([C:24]2[CH:2]=[C:3]([C:6]3[S:10][C:9]([NH:11][C:12]4[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=4)=[N:8][CH:7]=3)[CH:4]=[CH:5][CH:29]=2)=[CH:20]1

Participants

3

Reactant 2

HCID 112888354-(5-Thiophen-3-yl-thiazol-2-yl-amino)-phenolHCID 58923511(3-Thiophen-3-yl-phenyl)-acetaldehyde

Product 1

HCID 589235064-[5-(3-Thiophen-3-yl-phenyl)-thiazol-2-ylamino]-phenol

Procedure

The title compound is prepared as described in Example 12 (Procedure B) for 4-(5-thiophen-3-yl-thiazol-2-yl-amino)-phenol but starting from (3-thiophen-3-yl-phenyl)-acetaldehyde (Example 25). The title compound: ES-MS: 350.9 [M+H]+; single peak at tR=4.16 min (System 2).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-a965e684f7b345d3a24bc071a3a601bd
Source dataset
uspto-grants-2010_09
Patent number
US07795288B2

Reaction notes

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