HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron tribromide → 3-Methyl-4-(5-thiophen-3-yl-thiazol-2-ylamino)-phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 4-{2-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamino]-thiazol-5-yl}-phenol | HCID 11188206 | — |
| Reactant | (4-Methoxy-2-methyl-phenyl)-(5-thiophen-3-yl-thiazol-2-yl)-amine | HCID 58923520 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 3-Methyl-4-(5-thiophen-3-yl-thiazol-2-ylamino)-phenol | HCID 58923508 | — |
Reaction Steps
The title compound is prepared as described in Example 7 for 4-{2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-thiazol-5-yl}-phenol but starting from (4-methoxy-2-methyl-phenyl)-(5-thiophen-3-yl-thiazol-2-yl)-amine and using 4 equivalents of BBr3. Title compound: ES-MS: 289.0 [M+H]+; single peak at tR=3.33 min (System 2); Rf=0.15 (CH2Cl2/MeOH, 95/5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795288B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-8fb96b38c221475190b3f03e52f0f76c |
| Source note | uspto-grants-2010_09 |