4-(5-Thiophen-3-yl-thiazol-2-yl-amino)-phenol → (4-Methoxy-2-methyl-phenyl)-(5-thiophen-3-yl-thiazol-2-yl)-amine

HRID 1713677Notes

Reaction equation

HRID 1713677 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6]2SC(NC3C=CC(O)=CC=3)=N[CH:7]=2)=[CH:2]1.S1C=CC(C2C=C(CC=O)C=CC=2)=C1.[CH3:33][O:34][C:35]1[CH:40]=[CH:39][C:38]([NH:41][C:42]([NH2:44])=[S:43])=[C:37]([CH3:45])[CH:36]=1>>[CH3:33][O:34][C:35]1[CH:40]=[CH:39][C:38]([NH:41][C:42]2[S:43][C:6]([C:3]3[CH:4]=[CH:5][S:1][CH:2]=3)=[CH:7][N:44]=2)=[C:37]([CH3:45])[CH:36]=1

Participants

4

Reactant 3

HCID 112888354-(5-Thiophen-3-yl-thiazol-2-yl-amino)-phenolHCID 20481024(4-Methoxy-2-methylphenyl)thioureaHCID 58923511(3-Thiophen-3-yl-phenyl)-acetaldehyde

Product 1

HCID 58923520(4-Methoxy-2-methyl-phenyl)-(5-thiophen-3-yl-thiazol-2-yl)-amine

Procedure

The title compound is prepared as described in Example 12 (Procedure B) for 4-(5-thiophen-3-yl-thiazol-2-yl-amino)-phenol but starting from (3-thiophen-3-yl-phenyl)-acetaldehyde (Example 25) and (4-methoxy-2-methyl-phenyl)-thiourea. The title compound: ES-MS: 303.0 [M+H]+; single peak at tR=3.96 min (System 2).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-afe45da642f5427bb2cd2e32875a51fa
Source dataset
uspto-grants-2010_09
Patent number
US07795288B2

Reaction notes

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