HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron tribromide → 4-(5-Thiophen-3-yl-thiazol-2-ylamino)-3-trifluoromethyl-phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 4-{2-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamino]-thiazol-5-yl}-phenol | HCID 11188206 | — |
| Reactant | (4-Methoxy-2-trifluoromethyl-phenyl)-(5-thiophen-3-yl-thiazol-2-yl)-amine | HCID 58923518 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 4-(5-Thiophen-3-yl-thiazol-2-ylamino)-3-trifluoromethyl-phenol | HCID 58923523 | — |
Reaction Steps
The title compound is prepared as described in Example 7 for 4-{2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-thiazol-5-yl}-phenol but starting from (4-methoxy-2-trifluoromethyl-phenyl)-(5-thiophen-3-yl-thiazol-2-yl)-amine and using 4 equivalents of BBr3. Title compound: ES-MS: 342.9 [M+H]+; single peak at tR=3.71 min (System 2); Rf=0.47 (CH2Cl2/MeOH, 90/10).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795288B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-0661433be37b4e70a79f70e882d7326f |
| Source note | uspto-grants-2010_09 |