HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1713681Generated: November 3, 2026
Diisopropylethylamine → (4-Methoxy-2-trifluoromethyl-phenyl)-(5-thiophen-3-yl-thiazol-2-yl)-amine
https://huagongshe.com/reaction/1713681
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | 4-(5-Thiophen-3-yl-thiazol-2-yl-amino)-phenol | HCID 11288835 | — |
| Reactant | (4-Methoxy-2-trifluoromethyl-phenyl)-thiourea | HCID 58923517 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | (4-Methoxy-2-trifluoromethyl-phenyl)-(5-thiophen-3-yl-thiazol-2-yl)-amine | HCID 58923518 | — |
Reaction Steps
The title compound is prepared as described in Example 12 (Procedure B) for 4-(5-thiophen-3-yl-thiazol-2-yl-amino)-phenol but starting from (4-methoxy-2-trifluoromethyl-phenyl)-thiourea. After addition of the thiourea, the reaction mixture is heated to 50° C. for 30 min. The mixture is heated to 70° C. for 16 h, after addition of DIEA. The title compound: ES-MS: 357.0 [M+H]+; single peak at tR=4.36 min (System 2); Rf=0.56 (CH2Cl2/MeOH, 95/5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07795288B2 |
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| Source dataset | uspto-grants-2010_09 |
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| ORD ID | ord-8b9cd22d79a7460ba0663620e20ac4ef |
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| Source note | uspto-grants-2010_09 |
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