反应详情

温度

50 °C

The title compound is prepared as described in Example 12 (Procedure B) for 4-(5-thiophen-3-yl-thiazol-2-yl-amino)-phenol but starting from (4-methoxy-2-trifluoromethyl-phenyl)-thiourea. After addition of the thiourea, the reaction mixture is heated to 50° C. for 30 min. The mixture is heated to 70° C. for 16 h, after addition of DIEA. The title compound: ES-MS: 357.0 [M+H]+; single peak at tR=4.36 min (System 2); Rf=0.56 (CH2Cl2/MeOH, 95/5).

1. customThe title compound is prepared
2. temperatureThe mixture is heated to 70° C. for 16 h