HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloroethyldiisopropylammonium chloride → [4-(2-Diisopropylamino-ethoxy)-2-trifluoromethyl-phenyl]-(5-thiophen-3-yl-thiazol-2-yl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloroethyldiisopropylammonium chloride | HCID 77942 | — |
| Reactant | {5-[4-(3-Dimethylamino-propoxy)-phenyl]-thiazol-2-yl}phenyl-amine | HCID 11245147 | — |
| Reactant | 4-(5-Thiophen-3-yl-thiazol-2-ylamino)-3-trifluoromethyl-phenol | HCID 58923523 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | [4-(2-Diisopropylamino-ethoxy)-2-trifluoromethyl-phenyl]-(5-thiophen-3-yl-thiazol-2-yl)-amine | HCID 58923535 | — |
Reaction Steps
The title compound is prepared as described in Example 8 for {5-[4-(3-dimethylamino-propoxy)-phenyl]-thiazol-2-yl}phenyl-amine but starting from 4-(5-thiophen-3-yl-thiazol-2-ylamino)-3-trifluoromethyl-phenol (Example 28) and using (2-chloroethyl)-diisopropylamine hydrochloride. The title compound: ES-MS: 469.9 [M+H]+; single peak at tR=3.67 min (System 2); Rf=0.38 (CH2Cl2/MeOH, 90/10).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795288B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-35ef7f08960743b58cdc1607196788f7 |
| Source note | uspto-grants-2010_09 |