2-Acetylthiophene → HCID 58923507, compound

HRID 1713694Notes

Reaction equation

HRID 1713694 reaction equation
[C:1]([C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)(=O)[CH3:2].[CH2:9]([N:11]([CH2:32][CH3:33])[CH2:12][CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22]2C=C(C3C=CSC=3)[NH:24][N:23]=2)=[CH:17][CH:16]=1)[CH3:10]>C(Cl)Cl.CO>[CH2:32]([N:11]([CH2:9][CH3:10])[CH2:12][CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22]2[CH:2]=[C:1]([C:4]3[S:5][CH:6]=[CH:7][CH:8]=3)[NH:24][N:23]=2)=[CH:17][CH:16]=1)[CH3:33]

Participants

4

Reactant 2

HCID 69202-AcetylthiopheneHCID 11428258HCID 11428258, compound

Product 1

HCID 58923507HCID 58923507, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared as described in Example 33 but using 2-acetylthiophene and diethyl-[2-(4-isothiocyanato-phenoxy)-ethyl]-amine (Example 37). Title compound: ES-MS: 357.1 [M+H]+; single peak at tR=2.98 min (System 2); Rf=0.11 (CH2Cl2/MeOH, 80/20).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-e0823d2f85a44a748d61be4821f36024
Source dataset
uspto-grants-2010_09
Patent number
US07795288B2

Reaction notes

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