Hydrazine hydrate (1:1) → HCID 59464167, compound

HRID 1713789Notes

Reaction equation

HRID 1713789 reaction equation
O.[NH2:2][NH2:3].[N:4]1([C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:22])[C:18](OC)=[O:19])=[CH:12][CH:11]=2)[CH2:9][CH2:8][O:7][CH2:6][CH2:5]1>CO>[NH:2]([C:18](=[O:19])[C:17]([NH:16][C:13]1[CH:14]=[CH:15][C:10]([N:4]2[CH2:9][CH2:8][O:7][CH2:6][CH2:5]2)=[CH:11][CH:12]=1)=[O:22])[NH2:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 59464311HCID 59464311, compound2×

Product 1

HCID 59464167HCID 59464167, compoundYield 95.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
75 °C

Procedure

Hydrazine hydrate (1.25 mL, 25 mmol) was added to a stirred suspension of methyl [(4-morpholin-4-ylphenyl)amino](oxo)acetate (intermediate 1, 6.6 g, 25 mmol) in methanol (150 mL). The reaction was heated to 75° C. for 2 h during which time the precipitate thickened. After cooling the precipitate was filtered and washed with diethyl ether (50 mL) and dried to give the title compound (6.32 g, 94%):

Workup

  1. temperatureAfter cooling the precipitate
  2. filtrationwas filtered
  3. washwashed with diethyl ether (50 mL)
  4. customdried

Sources & evidence

ORD record
ord-8797ce311604493fa237463087be65a0
Source dataset
uspto-grants-2010_09
Patent number
US07795283B2

Reaction notes

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