[4-(4-Acetylpiperazin-1-yl)-3-methylphenyl]amine → 4-(4-Acetyl-1,4-diazepan-1-yl)aniline

HRID 1713809Notes

Reaction equation

HRID 1713809 reaction equation
C(N1CCN(C2C=CC(N)=CC=2C)CC1)(=O)C.[C:18]([N:21]1[CH2:27][CH2:26][CH2:25][N:24]([C:28]2[CH:33]=[CH:32][C:31]([N+:34]([O-])=O)=[CH:30][CH:29]=2)[CH2:23][CH2:22]1)(=[O:20])[CH3:19]>>[C:18]([N:21]1[CH2:27][CH2:26][CH2:25][N:24]([C:28]2[CH:33]=[CH:32][C:31]([NH2:34])=[CH:30][CH:29]=2)[CH2:23][CH2:22]1)(=[O:20])[CH3:19]

Participants

3

Reactant 2

HCID 5311936[4-(4-Acetylpiperazin-1-yl)-3-methylphenyl]amineHCID 594642511-Acetyl-4-(4-nitrophenyl)-1,4-diazepane2×

Product 1

HCID 288091234-(4-Acetyl-1,4-diazepan-1-yl)anilineYield 97%

Procedure

Following the general procedure of Intermediate 36 but using 1-acetyl-4-(4-nitrophenyl)-1,4-diazepane (Intermediate 70) as starting material there was thus obtained the title compound in 97% yield; 1H NMR δ: 6.55-6.46 (4H, m), 4.30 (2H, br s), 3.59-3.48 (3H, m), 3.41-3.26 (5H, m), 1.99-1.72 (5H, m); MS m/e MH+: 234.

Sources & evidence

ORD record
ord-7ba91c56af9c40caa17de76e0ea347bb
Source dataset
uspto-grants-2010_09
Patent number
US07795283B2

Reaction notes

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