HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Bromo-4-nitrophenyl)morpholine → 3-Bromo-4-morpholinoaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Bromo-4-nitrophenyl)morpholine | HCID 2765887 | — |
| Reactant | [4-(4-Acetylpiperazin-1-yl)-3-methylphenyl]amine | HCID 5311936 | — |
| Product | 3-Bromo-4-morpholinoaniline | HCID 675072 | — |
Reaction Steps
Following the general procedure of Intermediate 36 but using 4-(2-bromo-4-nitrophenyl)morpholine as starting material and allowing 5 h for hydrogenation and subsequently purifying by chromatography eluting with EtOAc/isohexane there was thus obtained the title compound (Intermediate 75) in 24% yield; 1H NMR δ 6.90 (1H, d), 6.80 (1H, s), 6.50 (1H, dd), 5.00 (2H, s), 5.40 (1H, d), 3.70-3.60 (4H, m), 2.80-2.70 (4H, m); MS m/e MH+ 258.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795283B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-f12c3493c41640339bc33624ee87273f |
| Source note | uspto-grants-2010_09 |