Methyl oxo{[4-(propylsulphonyl)phenyl]amino}acetate → 2-hydrazino-2-oxo-N-[4-(propylsulfonyl)phenyl]acetamide

HRID 1713865Notes

Reaction equation

HRID 1713865 reaction equation
[NH:1]([C:3](=[O:24])[C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C@H]2CC[C@H](CC(OC)=O)CC2)=[CH:9][CH:8]=1)=[O:5])[NH2:2].O=C(NC1C=C[C:35]([S:38](CCC)(=[O:40])=[O:39])=[CH:34][CH:33]=1)C(OC)=O>>[NH:1]([C:3](=[O:24])[C:4]([NH:6][C:7]1[CH:8]=[CH:9][C:10]([S:38]([CH2:35][CH2:34][CH3:33])(=[O:40])=[O:39])=[CH:11][CH:12]=1)=[O:5])[NH2:2]

Participants

3

Reactant 2

HCID 59464270Methyl oxo{[4-(propylsulphonyl)phenyl]amino}acetateHCID 178500682HCID 178500682, compound

Product 1

HCID 594641712-hydrazino-2-oxo-N-[4-(propylsulfonyl)phenyl]acetamide

Procedure

The procedure described for Intermediate 43 (part iv) was followed starting with methyl oxo{[4-(propylsulphonyl)phenyl]amino}acetate to give the title compound (Intermediate 97); 1H NMR δ 0.85-0.97 (m, 3H), 1.46-1.65 (m, 2H), 3.18-3.27 (m, 2H), 4.77 (s, 2H), 7.85 (d, 2H), 8.10 (d, 2H), 10.44 (s, 1H), 11.09 (s, 1H); MS m/e MH+ 286.

Sources & evidence

ORD record
ord-62966620831e4f8dbb29044bb20e8ceb
Source dataset
uspto-grants-2010_09
Patent number
US07795283B2

Reaction notes

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