反应详情

温度

80 °C

To a suspension of [trans-4-(4-{[(benzyloxy)carbonyl]amino}phenyl)cyclohexyl]acetic acid (516 mg, 1.40 mmol) in tert-butanol (3 mL) under an inert atmosphere was added triethylamine (0.45 mL, 3.23 mmol) and diphenyl phosphorylazide (0.70 mL, 3.23 mmol) and the mixture heated to 80° C. for 24 hours. Upon cooling the mixture was partitioned between EtOAc (100 mL) and H2O (20 mL). The aqueous phase was further extracted with DCM (2×20 mL) and the combined organics dried (MgSO4), filtered and evaporated. Purification by chromatography through silica gave the title compound (525 mg, 86%) as a white solid. 1H NMR (CDCl3) δ 0.96-1.07 (2H, m), 1.30-1.44 (12H, m), 1.78-1.85 (4H, m), 2.33-2.39 (1H, m), 2.94 (2H, t), 4.52 (1H, s), 5.12 (2H, s), 6.51 (1H, s), 7.04-7.07 (2H, m), 7.19-7.34 (7H, m)

1. temperatureUpon cooling the mixture
2. customwas partitioned between EtOAc (100 mL) and H2O (20 mL)
3. extractionThe aqueous phase was further extracted with DCM (2×20 mL)
4. dry with materialthe combined organics dried (MgSO4)
5. filtrationfiltered
6. customevaporated
7. customPurification by chromatography through silica