Hydrazine hydrate (1:1) → HCID 178453588, compound

HRID 1713886Notes

Reaction equation

HRID 1713886 reaction equation
O.[NH2:2][NH2:3].[C:4]([O:8][C:9]([NH:11][CH2:12][C@H:13]1[CH2:18][CH2:17][C@H:16]([C:19]2[CH:24]=[CH:23][C:22]([NH:25][C:26](=[O:31])[C:27]([O:29]C)=O)=[CH:21][CH:20]=2)[CH2:15][CH2:14]1)=[O:10])([CH3:7])([CH3:6])[CH3:5]>CCO>[NH:2]([C:27](=[O:29])[C:26]([NH:25][C:22]1[CH:21]=[CH:20][C:19]([C@H:16]2[CH2:17][CH2:18][C@H:13]([CH2:12][NH:11][C:9](=[O:10])[O:8][C:4]([CH3:6])([CH3:7])[CH3:5])[CH2:14][CH2:15]2)=[CH:24][CH:23]=1)=[O:31])[NH2:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178501860HCID 178501860, compound

Product 1

HCID 178453588HCID 178453588, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared using hydrazine hydrate in EtOH from methyl {[4-(trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)phenyl]amino}(oxo)acetate as described for Intermediate 18.1 1H NMR δ 0.99-1.06 (2H, m), 1.37-1.42 (12H, m), 1.77-1.80 (4H, m), 2.39-2.49 (1H, m), 2.81 (2H, t), 4.60 (2H, s), 6.80 (1H, t), 7.19 (2H, d), 7.68 (2H, d), 10.21 (1H, s), 10.45 (1H, s)

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0504506c6fd94130a2383dc9d916cd46
Source dataset
uspto-grants-2010_09
Patent number
US07795283B2

Reaction notes

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