N-Isopropylacrylamide → HCID 131728325, compound

HRID 1713954Notes

Reaction equation

HRID 1713954 reaction equation
[CH3:1][CH:2]([NH:4][C:5]([CH:7]=[CH2:8])=[O:6])[CH3:3].[C:9]([O:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)(=[O:12])[CH:10]=[CH2:11].N(C(C)(CC)C#N)=NC(C)(CC)C#N>C(OCC)(=O)C>[CH3:1][CH:2]([NH:4][C:5]([CH:7]=[CH2:8])=[O:6])[CH3:3].[C:9]([O:13][CH2:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)(=[O:12])[CH:10]=[CH2:11]

Participants

5

Reactant 3

HCID 16637N-IsopropylacrylamideHCID 770662-Propenoic acid, 2-phenylethyl esterHCID 930792,2'-Azobis(2-methylbutyronitrile)

Product 1

HCID 131728325HCID 131728325, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A 25 ml reaction vessel was charged with 11.86 g ethyl acetate, 3 g (0.007 mol) TRIS, 1 g (0.009 mol) NIPAM, 0.14 g (0.0008 mol) 2-phenylethyl acrylate and 0.082 g. 2,2′-azobis(2-methylbutanenitrile). After nitrogen flushing for 3 minutes, the vessel was closed and placed in an oil bath. The polymerization was run for 5 hours at 69-74° C. The polymer was precipitated into water, filtered, dissolved in acetone, precipitated in water and dried at 50° C. The polymer was compatible with HMDS at 10 wt % polymer in the liquid.

Workup

  1. customA 25 ml reaction vessel
  2. customthe vessel was closed
  3. customplaced in an oil bath
  4. waitThe polymerization was run for 5 hours at 69-74° C
  5. customThe polymer was precipitated into water
  6. filtrationfiltered
  7. dissolutiondissolved in acetone
  8. customprecipitated in water
  9. customdried at 50° C

Sources & evidence

ORD record
ord-30a2de71c8064c66b15c50beb7ca0a4e
Source dataset
uspto-grants-2010_09
Patent number
US07795326B2

Reaction notes

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