N-Isopropylacrylamide → HCID 131728326, compound

HRID 1713955Notes

Reaction equation

HRID 1713955 reaction equation
[CH3:1][CH:2]([NH:4][C:5]([CH:7]=[CH2:8])=[O:6])[CH3:3].[C:9]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)(=[O:13])[C:10]([CH3:12])=[CH2:11].N(C(C)(CC)C#N)=NC(C)(CC)C#N>C(OCC)(=O)C>[CH3:1][CH:2]([NH:4][C:5]([CH:7]=[CH2:8])=[O:6])[CH3:3].[C:9]([O:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)(=[O:13])[C:10]([CH3:12])=[CH2:11]

Participants

5

Reactant 3

HCID 16637N-IsopropylacrylamideHCID 17236Benzyl methacrylateHCID 930792,2'-Azobis(2-methylbutyronitrile)

Product 1

HCID 131728326HCID 131728326, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A 25 ml reaction vessel was charged with 11.86 g ethyl acetate, 3 g (0.007 mol) TRIS, 1 g (0.009 mol) NIPAM, 0.14 g (0.0008 mol) benzyl methacrylate and 0.082 g. 2,2′-azobis(2-methylbutanenitrile). After nitrogen flushing for 3 minutes, the vessel was closed and placed in an oil bath. The polymerization was run for 6 hours at 70-78° C. The polymer was precipitated into water, filtered, dissolved in acetone, precipitated in water and dried at 50° C. The polymer was compatible with HMDS at 10 wt % polymer in the liquid with the presence of macroscopic gel particles.

Workup

  1. customA 25 ml reaction vessel
  2. customthe vessel was closed
  3. customplaced in an oil bath
  4. waitThe polymerization was run for 6 hours at 70-78° C
  5. customThe polymer was precipitated into water
  6. filtrationfiltered
  7. dissolutiondissolved in acetone
  8. customprecipitated in water
  9. customdried at 50° C

Sources & evidence

ORD record
ord-51b78185faca4029a7b9c723636691b7
Source dataset
uspto-grants-2010_09
Patent number
US07795326B2

Reaction notes

Loading…