2-Morpholinoethylamine → HCID 68505302, compound

HRID 1713991Notes

Reaction equation

[C:1]([O:5][C:6](=[O:40])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:17]([O:19][CH3:20])=[O:18])[CH:15]=2)[C:10]([CH:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)=[C:9]1[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[CH2:33][NH:34][CH2:35][CH2:36][N:37]([CH3:39])[CH3:38])([CH3:4])([CH3:3])[CH3:2].N1(CCN)C[CH2:45][O:44][CH2:43]C1>>[C:1]([O:5][C:6](=[O:40])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:17]([O:19][CH3:20])=[O:18])[CH:15]=2)[C:10]([CH:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)=[C:9]1[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[CH2:33][NH:34][CH2:35][CH2:36][N:37]1[CH2:39][CH2:45][O:44][CH2:43][CH2:38]1)([CH3:2])([CH3:4])[CH3:3]

Participants

Reactant 2

HCID 4082852-Morpholinoethylamine

HCID 68505409HCID 68505409, compound

Product 1

HCID 68505302HCID 68505302, compoundYield 92%

Procedure

The title compound was obtained following the same procedure described in Example 1, Step 3 for the synthesis of methyl 1-(2-tert-butoxy-2-oxoethyl)-3-cyclohexyl-2-[2-({[2-(dimethylamino)ethyl]amino}methyl)phenyl]-1H-indole-6-carboxylate, using 2-morpholin-4-ylethyl amine instead of N,N-dimethylethane-1,2-diamine. The title compound was obtained in a 92% yield; MS (ES+) m/z 590 (M+H)+

Sources & evidence

ORD record: ord-21f27c74b08247c68aca50de75c59035
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07795247B2

Reaction notes

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