methyl (7R)-7-azido-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate → Methyl(7r)-7-amino-14-cyclohexyl-7,8-dihydro-6h-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Participants

Reaction Steps

A solution of the foregoing product from Step 2 in MeOH (0.1 M) containing palladium on charcoal (10%, w/w) was stirred under hydrogen at atmospheric pressure for 4 h. The catalyst was filtered off and the solution was concentrated to dryness under reduced pressure to afford the title compound (92%) MS (ES+) m/z 405 (M+H)+. MS (ES+) m/z 405 (M+H)+; %; [α]D20=+46.4 (c=1, CHCl3).

Provenance & Evidence