反应详情

A solution of methyl 14-cyclohexyl-7-(hydroxymethyl)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate (from step 2) in dry DCM (0.1 M) was treated with DMP (1.2 eq.) and the resulting solution was stirred for 2 h at RT. The reaction mixture was diluted with EtOAc and washed with a 1:1 (v/v) mixture of sodium thiosulfate and NaHCO3 (both aqueous saturated solutions), then with brine. Drying over Na2SO4, filtration and concentration i. vac. gave the crude methyl 14-cyclohexyl-7-formyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate, which without further purification.

1. washwashed with a 1:1 (v/v) mixture of sodium thiosulfate and NaHCO3 (both aqueous saturated solutions), then with brine
2. dry with materialDrying over Na2SO4, filtration and concentration i