HCID 57820042, compound → HCID 57820077, compound

Participants

Reaction Steps

To a solution of acetic acid (4-bromo-phenyl)-(4-trifluoromethyl-phenylcarbamoyl)-methyl ester (5.7 g, 13.7 mmol) in THF (20 mL) was added LiOH monohydrate (0.863 g, 20.5 mmol) in water (12 mL) dropwise at room temperature. After stirring an additional hour at room temperature, the mixture was extracted with ethyl acetate. The ethyl acetate layer was dried over sodium sulfate, filtered, and concentrated in vacuo to obtain white solid (5.04 g, 98.8%).

Provenance & Evidence