HCID 57820042, compound → HCID 57820077, compound

HRID 1714163Notes

Reaction equation

HRID 1714163 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:22]C(=O)C)[C:9](=[O:21])[NH:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)=[CH:4][CH:3]=1>C1COCC1.O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([OH:22])[C:9]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:19])([F:20])[F:18])=[CH:13][CH:12]=2)=[O:21])=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 57820042HCID 57820042, compound

Product 1

HCID 57820077HCID 57820077, compoundYield 98.8%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of acetic acid (4-bromo-phenyl)-(4-trifluoromethyl-phenylcarbamoyl)-methyl ester (5.7 g, 13.7 mmol) in THF (20 mL) was added LiOH monohydrate (0.863 g, 20.5 mmol) in water (12 mL) dropwise at room temperature. After stirring an additional hour at room temperature, the mixture was extracted with ethyl acetate. The ethyl acetate layer was dried over sodium sulfate, filtered, and concentrated in vacuo to obtain white solid (5.04 g, 98.8%).

Workup

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialThe ethyl acetate layer was dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-54de751aeb7f4fdd8e4a1962e5b055e4
Source dataset
uspto-grants-2010_09
Patent number
US07795315B2

Reaction notes

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