反应详情

A solution of 140 mg (0.33 mmol) of tert-butyl {3-[1-(3-methylbut-2-enyl)-6-nitro-1H-benzimidazol-2-ylsulfanyl]propyl}carbamate in 15 ml of ethanol was added dropwise to a suspension of 93 mg (1.66 mmol) of iron and 16 mg (0.30 mmol) of ammonium chloride in 1.5 ml of water and boiled at reflux for 3 hours. The catalyst was filtered off and washed with ethanol. The filtrate was concentrated under reduced pressure. The 138 mg of the desired product thus obtained were used in the next stage without further purification.

1. temperatureat reflux for 3 hours
2. filtrationThe catalyst was filtered off
3. washwashed with ethanol
4. concentrationThe filtrate was concentrated under reduced pressure