Trifluoroacetic acid → HCID 178523667, compound

HRID 1714391Notes

Reaction equation

HRID 1714391 reaction equation
[F:1][C:2]1[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([CH2:11][CH2:12][CH:13]2[CH2:18][CH2:17][CH:16]([NH2:19])[CH2:15][CH2:14]2)[CH2:7][CH2:6]1.FC(F)(F)C(O)=O.[N:32]1[C:41]2[C:36](=[CH:37][C:38]([C:42](O)=[O:43])=[CH:39][CH:40]=2)[CH:35]=[CH:34][CH:33]=1>>[F:1][C:2]1[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([CH2:11][CH2:12][C@H:13]2[CH2:14][CH2:15][C@H:16]([NH:19][C:42]([C:38]3[CH:37]=[C:36]4[C:41](=[CH:40][CH:39]=3)[N:32]=[CH:33][CH:34]=[CH:35]4)=[O:43])[CH2:17][CH2:18]2)[CH2:7][CH2:6]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 825716-Quinolinecarboxylic acidHCID 68506251HCID 68506251, compound

Product 1

HCID 178523667HCID 178523667, compound

Procedure

According to the procedure described in Example 22.5, the title compound was synthesized from Trans(4-{2-[4-(2,4-Difluoro-phenoxy)-piperidin-1-yl]-ethyl}-cyclohexylamine; trifluoro-acetic acid salt and quinoline-6-carboxylic acid.

Sources & evidence

ORD record
ord-522e5fe1f3f34e74b4a6d4e0c2f64b9f
Source dataset
uspto-grants-2010_09
Patent number
US07795437B2

Reaction notes

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