Trifluoroacetic acid → HCID 178510121, compound

HRID 1714394Notes

Reaction equation

C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH:19]([O:22][C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=3[C:30]#[N:31])[CH2:18][CH2:17]2)[CH2:10][CH2:9]1)(C)(C)C.[F:33][C:34]([F:39])([F:38])[C:35]([OH:37])=[O:36]>>[F:33][C:34]([F:39])([F:38])[C:35]([OH:37])=[O:36].[NH2:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][CH2:15][N:16]2[CH2:17][CH2:18][CH:19]([O:22][C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=3[C:30]#[N:31])[CH2:20][CH2:21]2)[CH2:10][CH2:9]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 178453906HCID 178453906, compound

Product 1

HCID 178510121HCID 178510121, compound

Procedure

The title compound was prepared analogously to example 1 (1.4) starting from Trans(4-{2-[4-(2-Cyano-4-fluoro-phenoxy)-piperidin-1-yl]-ethyl}-cyclohexyl)-carbamic acid tert-butyl ester and trifluoroacetic acid MS (m/e): 346.2 (M+H+).

Sources & evidence

ORD record: ord-ff17f8ba64e647ffafb5b08956d21d8b
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07795437B2

Reaction notes

Loading…