Oxane-4-carboxylic acid → HCID 178523669, compound

HRID 1714399Notes

Reaction equation

HRID 1714399 reaction equation
[F:1][C:2]1[CH:23]=[C:22]([F:24])[C:21]([F:25])=[CH:20][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([CH2:11][CH2:12][C@H:13]2[CH2:18][CH2:17][C@H:16]([NH2:19])[CH2:15][CH2:14]2)[CH2:7][CH2:6]1.[O:26]1[CH2:31][CH2:30][CH:29]([C:32](O)=[O:33])[CH2:28][CH2:27]1>>[F:1][C:2]1[CH:23]=[C:22]([F:24])[C:21]([F:25])=[CH:20][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([CH2:11][CH2:12][C@H:13]2[CH2:14][CH2:15][C@H:16]([NH:19][C:32]([CH:29]3[CH2:30][CH2:31][O:26][CH2:27][CH2:28]3)=[O:33])[CH2:17][CH2:18]2)[CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 219302Oxane-4-carboxylic acidHCID 178511519HCID 178511519, compound

Product 1

HCID 178523669HCID 178523669, compound

Procedure

According to the synthesis of example 19 the title compound was prepared from Trans(4-{2-[4-(2,4,5-trifluoro-phenoxy)-piperidin-1-yl]-ethyl}-cyclohexyl)-amine and tetrahydro-pyran-4-carboxylic acid. Preparative HPLC on reversed phase eluting with acetonitrile/water yielded the title compound. MS (m/e): 469.5 (M+H+).

Workup

  1. washPreparative HPLC on reversed phase eluting with acetonitrile/water

Sources & evidence

ORD record
ord-cf8fba6d3c1a4d049bdb917fd9bab0e1
Source dataset
uspto-grants-2010_09
Patent number
US07795437B2

Reaction notes

Loading…