2-Chloro-6-fluorobenzonitrile → HCID 68499903, compound

HRID 1714402Notes

Reaction equation

HRID 1714402 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6](F)[C:3]=1[C:4]#[N:5].C(OC([N:18]1[CH2:23][CH2:22][CH:21]([OH:24])[CH2:20][CH2:19]1)=O)(C)(C)C>>[ClH:1].[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([O:24][CH:21]2[CH2:22][CH2:23][NH:18][CH2:19][CH2:20]2)[C:3]=1[C:4]#[N:5]

Participants

3

Reactant 2

HCID 695872-Chloro-6-fluorobenzonitrileHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Product 1

HCID 68499903HCID 68499903, compound

Procedure

2-Chloro-6-(piperidin-4-yloxy)-benzonitrile hydrochloride was prepared in a manner analogous to that described in example 59.2 from 2-chloro-6-fluoro-benzonitrile and 4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester. White solid. MS (m/z): 237.0 ([M+H]+).

Sources & evidence

ORD record
ord-0caaa75c2a8445a898e3ebe25acda033
Source dataset
uspto-grants-2010_09
Patent number
US07795437B2

Reaction notes

Loading…