反应详情

A mixture of 5-(3-bromo-propoxy)-6-methoxy-indan-1-one (Intermediate J) (2.0 g, 0.0066 mole) and pyrrolidine (1.7 mL, 0.02 mole) was stirred in 50 mL of DME (1,2-Dimethoxyethane) at room temperature overnight under Argon. The reaction was quenched with water (150 mL) and made acidic with 1 N HCl (50 mL). The water solution was washed with ethyl acetate, made basic with 3N NaOH (25 mL) and extracted with ethyl acetate. After washing with brine and drying over sodium sulfate, the solvent was removed in vacuo to yield the title compound. MS m/z 290 (M+H)+.

1. customThe reaction was quenched with water (150 mL)
2. washThe water solution was washed with ethyl acetate
3. extractionextracted with ethyl acetate
4. washAfter washing with brine
5. dry with materialdrying over sodium sulfate
6. customthe solvent was removed in vacuo