Ethanol → HCID 178510410, compound

HRID 1714655Notes

Reaction equation

HRID 1714655 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][C:24]([C:26]3[NH:27][CH:28]=[C:29]([C:31]#[N:32])[N:30]=3)=[O:25])=[C:19]([C:33]3[CH2:38][CH2:37][CH2:36][CH2:35][CH:34]=3)[CH:18]=2)[CH2:13][CH2:12]1)=[O:10])(C)(C)C.CCO.[C:43]([OH:49])([C:45]([F:48])([F:47])[F:46])=[O:44]>C(Cl)Cl>[F:46][C:45]([F:48])([F:47])[C:43]([OH:49])=[O:44].[NH2:7][CH2:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][C:24]([C:26]3[NH:27][CH:28]=[C:29]([C:31]#[N:32])[N:30]=3)=[O:25])=[C:19]([C:33]3[CH2:38][CH2:37][CH2:36][CH2:35][CH:34]=3)[CH:18]=2)[CH2:13][CH2:12]1)=[O:10]

Participants

5

Reactant 3

HCID 702EthanolHCID 6422Trifluoroacetic acidHCID 178453786HCID 178453786, compound

Product 1

HCID 178510410HCID 178510410, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of [2-(4-{4-[(4-cyano-1H-imidazole-2-carbonyl)-amino]-3-cyclohex-1-enyl-phenyl}-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester (as prepared in the previous step, 0.41 g, 0.77 mmol) in CH2Cl2 (20 mL) was treated with EtOH (0.2 mL) and TFA (6 mL). The mixture stirred at room temperature for 45 min, and the solvents were evaporated in vacuo. The crude material was used directly in the next step. LC-MS (ESI, m/z): Calcd. for C24H28N6O2 433.2 (M+H), found 433.2.

Workup

  1. customthe solvents were evaporated in vacuo

Sources & evidence

ORD record
ord-9575e40e6ad94d2590a694e211e10edf
Source dataset
uspto-grants-2010_09
Patent number
US07795279B2

Reaction notes

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