反应详情

1.07 g of o-chlorobenzoyl chloride was added to a solution in which 1.00 g of ethyl 2-amino-1,3-thiazole-4-carboxylate and 0.69 g of pyridine were dissolved in THF, under ice cooling. Then, after the reaction mixture was stirred at room temperature for 1 hr, it was poured into water and extracted with ethyl acetate. The organic layer was washed with an aqueous 2N-hydrochloric acid solution and dried on anhydrous magnesium sulfate. After distilling off the solvent, the crude product obtained was washed with a mixed solvent of hexane and t-butyl methyl ether to obtain 1.52 g of the aimed ethyl 2-(2-chlorobenzoyl)amino-1,3-thiazole-4-carboxylate.

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with an aqueous 2N-hydrochloric acid solution
3. dry with materialdried on anhydrous magnesium sulfate
4. distillationAfter distilling off the solvent
5. customthe crude product obtained
6. washwas washed with a mixed solvent of hexane and t-butyl methyl ether