反应详情

To a stirred solution of 3-phenylsulfonyl-8-piperazin-1-yl-quinoline hydrochloride (E2) (54 mg, 0.14 mmol) in glacial acetic acid (0.5 ml), at room temperature was added N-chlorosuccinimide (19 mg, 0.14 mmol). After 16 h the solvent was removed and the mono chlorinated product isolated by preparative reverse phase gradient chromatography (10-90% acetonitrile in water). After removal of the solvents the residue was dissolved in methanol and treated with a solution of hydrogen chloride in diethyl ether (1 M). The solvent was removed to afford the title compound (E10) (9 mg 17%);

1. customAfter 16 h the solvent was removed
2. customisolated by preparative reverse phase gradient chromatography (10-90% acetonitrile in water)
3. customAfter removal of the solvents the residue
4. dissolutionwas dissolved in methanol
5. additiontreated with a solution of hydrogen chloride in diethyl ether (1 M)
6. customThe solvent was removed