1,4-Dioxane hydrochloride → HCID 23155647, compound

HRID 1714763Notes

Reaction equation

HRID 1714763 reaction equation
[ClH:1].O1CCOCC1.[NH2:8][N:9]1[O:21][C:20]2[C:19]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][C:14]=3[S:13][C:12]=2[N:11]=[C:10]1[S:29][CH2:30][CH2:31][CH2:32][N:33]1[CH2:38][CH2:37][N:36]([C:39]2[CH:48]=[CH:47][C:46]3[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=3)[N:40]=2)[CH2:35][CH2:34]1>>[ClH:1].[ClH:1].[ClH:1].[NH2:8][N:9]1[O:21][C:20]2[C:19]3[CH2:18][CH2:17][NH:16][CH2:15][C:14]=3[S:13][C:12]=2[N:11]=[C:10]1[S:29][CH2:30][CH2:31][CH2:32][N:33]1[CH2:38][CH2:37][N:36]([C:39]2[CH:48]=[CH:47][C:46]3[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=3)[N:40]=2)[CH2:35][CH2:34]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 23155732HCID 23155732, compound

Product 1

HCID 23155647HCID 23155647, compoundYield 100%

Procedure

To 6 ml of 4N-hydrochloric acid-dioxane solution, 100 mg of 3-amino-7-tert-butoxycarbonyl-2-[3-(4-quinolin-2-ylpiperazin-1-yl)propylthio]-3,4,5,6,7,8-hexahydro-4-oxa-9-thia-1,3,7-triaza-9H-fluorene as synthesized in Example 1-13 was added and stirred for 2.5 hours. Distilling the solvent off under reduced pressure, 105 mg (100%) of 3-amino-2-[3-(4-quinolin-2-ylpiperazin-1-yl)propylthio]-3,4,5,6,7,8-hexahydro-4-oxa-9-thia-1,3,7-triaza-9H-fluorene trihydrochloride was obtained.

Workup

  1. additionwas added
  2. distillationDistilling the solvent off under reduced pressure

Sources & evidence

ORD record
ord-fda53713b93e41ea87e2f89c62ef038f
Source dataset
uspto-grants-2010_09
Patent number
US07799775B2

Reaction notes

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