1,4-Dioxane hydrochloride → HCID 23155647, compound

Participants

Reaction Steps

To 6 ml of 4N-hydrochloric acid-dioxane solution, 100 mg of 3-amino-7-tert-butoxycarbonyl-2-[3-(4-quinolin-2-ylpiperazin-1-yl)propylthio]-3,4,5,6,7,8-hexahydro-4-oxa-9-thia-1,3,7-triaza-9H-fluorene as synthesized in Example 1-13 was added and stirred for 2.5 hours. Distilling the solvent off under reduced pressure, 105 mg (100%) of 3-amino-2-[3-(4-quinolin-2-ylpiperazin-1-yl)propylthio]-3,4,5,6,7,8-hexahydro-4-oxa-9-thia-1,3,7-triaza-9H-fluorene trihydrochloride was obtained.

Provenance & Evidence