Water → HCID 802571, compound

HRID 1714778Notes

Reaction equation

HRID 1714778 reaction equation
[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[S-:13].[K+].[CH3:15]I.O>CN(C)C=O>[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[S:13][CH3:15]

Participants

5

Reactant 3

HCID 962WaterHCID 6328Methyl iodideHCID 23701454HCID 23701454, compound

Product 1

HCID 802571HCID 802571, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution 209 mg of potassium 3-amino-3H-quinazolin-4-one-2-thiolate in 5 ml of dimethylformamide, 141 mg of methyl iodide was added, and stirred for 20 minutes at room temperature. Water was added to the solution, followed by extraction with ethyl acetate and drying over anhydrous magnesium sulfate. Distilling the solvent off under reduced pressure, 161 mg (86%) of 3-amino-2-methylthio-3H-quinazolin-4-one was obtained.

Workup

  1. extractionfollowed by extraction with ethyl acetate
  2. dry with materialdrying over anhydrous magnesium sulfate
  3. distillationDistilling the solvent off under reduced pressure

Sources & evidence

ORD record
ord-78a64271e5e54bdf9227a2a1138c65e4
Source dataset
uspto-grants-2010_09
Patent number
US07799775B2

Reaction notes

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