HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(4-Quinoline-2-ylpiperazin-1-yl)hexanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 5-(4-quinolin-2-ylpiperazin-1-yl)hexanoate | HCID 23155655 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(4-Quinoline-2-ylpiperazin-1-yl)hexanoic acid | HCID 23155918 | 89.3% |
Reaction Steps
To 10 ml of 1N sodium hydroxide:ethanol=1:1 solution, 850 mg of methyl 5-(4-quinolin-2-ylpiperazin-1-yl)hexanoate as synthesized in above Step 7-14-B was added and heated under reflux for an hour. Cooling the system, 2N hydrochloric acid was added to make the pH7, and the precipitate was recovered by filtration and dried to provide 728 mg (89%) of 5-(4-quinoline-2-ylpiperazin-1-yl)hexanoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07799775B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-73ec2f9a360343ac864df29121ac3fce |
| Source note | uspto-grants-2010_09 |