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HRID1714787

反应详情

EQUATION

反应方程式

HRID 1714787 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：COC(=O)CCCC(C)N1CCN(c2ccc3ccccc3n2)CC1
HCID23155655

未命名化合物

PRODUCTS

生成物

1
结构：CC(CCCC(=O)O)N1CCN(c2ccc3ccccc3n2)CC1
HCID23155918

未命名化合物

收率 89.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

To 10 ml of 1N sodium hydroxide:ethanol=1:1 solution, 850 mg of methyl 5-(4-quinolin-2-ylpiperazin-1-yl)hexanoate as synthesized in above Step 7-14-B was added and heated under reflux for an hour. Cooling the system, 2N hydrochloric acid was added to make the pH7, and the precipitate was recovered by filtration and dried to provide 728 mg (89%) of 5-(4-quinoline-2-ylpiperazin-1-yl)hexanoic acid.

WORKUP

后处理

  1. additionwas added
  2. temperatureheated
  3. temperatureunder reflux for an hour
  4. additionwas added
  5. filtrationthe precipitate was recovered by filtration
  6. customdried